Description
Amphetamine and Dextroamphetamine IR tablets is a psychostimulant drug belonging to the drug class phenethylamine. Amphetamine + Dextroamphetamine is used in the treatment of attention deficit hyperactivity (ADHD) and narcolepsy.
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This drug is available in an immediate-release and extended-release formula.
ADHD: In the immediate-release form, an oral dose of 5 mg is administered every day and can be increased by 5 mg to 10 mg per day each week.
The maximum dose should not exceed 40 mg per day. For the extended-release version of this drug, an oral dose of 20 mg is administered in the morning.
The dose can be increased if necessary, but the maximum dose should not exceed 30 mg per day without consulting your doctor.
Narcolepsy: Doctors usually only prescribe the immediate-release version of this drug for narcolepsy. It is administered orally in doses ranging from 5 mg to 60 mg per day. The dose can be increased by 10 mg each day. The dose should not exceed 60 mg per day.
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Amphetamine + Dextroamphetamine is well absorbed in the gastrointestinal tract. Bioavailability is typically greater than 75% for dextroamphetamine. Absorption depends on the pH of the individual’s gastrointestinal tract. Basic pH increases absorption through the lipid-rich cell membranes of the gut. Acidic pH changes the drug to its water-soluble cationic (salt) form and is less absorbed. The drug is metabolized in the liver resulting in a variety of excreted metabolic products.
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